Meriwether County is a county in the West Central region of the U.S. state of Georgia. As of the 2020 census, the population was 20,613. The county seat is Greenville, home of the Meriwether County Courthouse. The county was formed on December 14, 1827, as the 73rd county in Georgia. It was named for David Meriwether, a general in the American Revolutionary War and member of Congress from Georgia. Meriwether County is part of the Atlanta-Sandy Springs-Roswell MSA.