Chatham County is a county located in the Piedmont area of the U.S. state of North Carolina. It is also the location of the geographic center of North Carolina, northwest of Sanford. As of the 2020 census, the population was 76,285. Its county seat is Pittsboro. Chatham County is part of the Durham-Chapel Hill, NC Metropolitan Statistical Area, which is also included in the Raleigh-Durham-Cary, NC Combined Statistical Area, which had an estimated population of 2,368,947 in 2023.