Marble Hill is a fourth-class city in central Bollinger County in Southeast Missouri, United States. Located at the intersection of State Highways 34 and 51, it is the largest city in Bollinger and serves as the county seat. The population was 1,388 at the 2020 census. The city was officially organized in July 1851 and is named after a marble-like rock. Marble Hill is part of the Cape Girardeau−Jackson, MO-IL Metropolitan Statistical Area.