Seton Hill Historic District is a historic district in Baltimore, Maryland. It was listed on the National Register of Historic Places in 1975.It includes St. Mary's Seminary Chapel, which is a National Historic Landmark. It also includes Mother Seton House, briefly home of St. Elizabeth Ann Seton, separately listed on the National Register. Seton Hill, Baltimore's former second French Quarter, is centered on the former St. Mary's Seminary and College, which was founded around 1791 by Sulpician priests who fled the French Revolution.