Palazzuolo sul Senio is a comune in the Metropolitan City of Florence in the Italian region Tuscany, located about 45 kilometres northeast of Florence. Palazzuolo sul Senio borders the following municipalities: Borgo San Lorenzo, Brisighella, Casola Valsenio, Castel del Rio, Firenzuola, Marradi. Since 2018, it has been designated as one of I Borghi più belli d'Italia.