Reynolds County is a county located in the Ozark Foothills Region in the Lead Belt of Missouri. As of the 2020 census, the population was 6,096. Its county seat is Centerville. The county was officially organized on February 25, 1845, and was named in honor of former Governor of Missouri Thomas Reynolds. The county is home to Johnson's Shut-Ins State Park, a popular tourist attraction in the state of Missouri.