Outagamie County is a county in the Fox Cities region of the U.S. state of Wisconsin, located in the northeast of the state. As of the 2020 Census, the population was 190,705. Its county seat is Appleton. Outagamie County is included in the Appleton, WI Metropolitan Statistical Area, which is also included in the Appleton-Neenah-Oshkosh, WI Combined Statistical Area. It was named for the historic Meskwaki Indians.