Hermleigh is a census-designated place in Scurry County, Texas, United States. Hermleigh lies on U.S. Route 84, ninety-six miles southeast of Lubbock, and has a population of 383 people at the 2020 census. A destructive low-end EF2 tornado struck the northwestern side of town on May 1, 2022, damaging or destroying mobile homes while also damaging a home, a garage, trailers, and vehicles. A 4.9 magnitude earthquake was reported by the United States Geological Survey on July 22, 2024.