Upper Sandusky is a city in and the county seat of Wyandot County, Ohio, United States, along the upper Sandusky River. The city lies approximately 59 miles south of Toledo and 62 miles north of Columbus. The population was 6,698 at the 2020 census. The city was founded in 1843 and named for an earlier Wyandot village of the same name, which was located nearby. It was named "Upper" because it is located near the headwaters of the Sandusky River, which flows into Lake Erie.