Leland is a city in Washington County, Mississippi, United States. It is located within the Mississippi Delta, on the banks of Deer Creek. The population was 4,481 at the 2010 census. It was once a railway town and had long been a center of cotton culture, which is still an important commodity crop in the rural area. It was once considered the second-largest city in Washington County in 1920 due to its rapid growth of residents, businesses, and schools.