Nenana(Lower Tanana: Toghotili; is a home rule city in the Yukon-Koyukuk Census Area of the Unorganized Borough in Interior Alaska. Nenana developed as a Lower Tanana community at the confluence where the tributary Nenana River enters the Tanana. The population was 378 at the 2010 census, down from 402 in 2000. Completed in 1923, the 700-foot-long Mears Memorial Bridge was built over the Tanana River as part of the territory's railroad project connecting Anchorage and Fairbanks.