Lettsworth is an unincorporated community located in the northern tip of Pointe Coupee Parish, Louisiana, United States. It lies on the east bank of the Atchafalaya River near its intersection with the Mississippi and Red rivers at the Old River Control Structure. As of 2005, the population is 202. The town's zip code is 70753. Blues musician Buddy Guy was born in Lettsworth in 1936. The father of journalist Howard K. Smith was originally from Lettsworth.