Lobeco is an unincorporated community and census-designated place located in Beaufort County, South Carolina, United States. According to the 2020 census, the population was 292. Situated about 10 miles north of Beaufort, it is a predominantly agricultural area that has retained its rural character. A small community area consisting of a library, post office, and produce market serve as an anchor for the surrounding community. It is served by U.S. Highway 21.