Neffsville is an unincorporated community in Manheim Township, Lancaster County, Pennsylvania, United States. As an unincorporated area, Neffsville has no formalized boundaries. The U.S. Geological Survey locates Neffsville at 40°6'0"N 76°18'20"W. The retail and restaurant center of Neffsville is near 2500 Lititz Pike. Lancaster, the county seat, is 4.5 miles to the south, and Lititz is 4 miles to the north.