Vignale Monferrato is a comune in the Province of Alessandria in the Italian region Piedmont, located about 60 kilometres east of Turin and about 20 kilometres northwest of Alessandria. Vignale Monferrato borders the following municipalities: Altavilla Monferrato, Camagna Monferrato, Casorzo, Frassinello Monferrato, Fubine, Lu e Cuccaro Monferrato and Olivola.