Santiago del Estero is the capital of Santiago del Estero Province in northern Argentina. It has a population of 252,192 inhabitants, making it the twelfth largest city in the country, with a surface area of 2,116 km2. It lies on the Dulce River and on National Route 9, at a distance of 1,042 km north-northwest from Buenos Aires. Estimated to be 455 years old, Santiago del Estero was the first city founded by Spanish settlers in the territory that is now Argentina.