Ocotillo is a census-designated place in Imperial County, California. Ocotillo is located 26 miles west of El Centro, The population was 215 at the 2020 census, down from 266 at the 2010 census and 296 at the 2000 census. It is part of the El Centro, California Metropolitan Statistical Area. Ocotillo was devastated by floods from Hurricane Kathleen in 1976; 3 people died. There is a cafe, a church, a small park, a community center, a small market, two bars, OHV rentals and a gas station.