Scott County is a county located in the southeastern portion of the U.S. state of Missouri. As of the 2020 census, the population was 38,059. Its county seat is Benton. The county was organized in 1821 and named for U.S. Representative John Scott, the first federal representative from Missouri. Scott County comprises the Sikeston, MO Micropolitan Statistical Area, which is also included in the Cape Girardeau-Sikeston, MO-IL Combined Statistical Area.