Chamkar Leu is a district of Kampong Cham province, Cambodia. The district capital is Chamkar Leu town. The town is located at the junction of National Roads 71 and 222 around 48 kilometres north east of the provincial capital at Kampong Cham city. The district is significant producer of rubber, both for domestic consumption and for export. Two large rubber co-operatives, Chamkar Andong Plantation and Chamkar Leu Plantation are located in the district.