Ohio County is a county located in the Northern Panhandle of the U.S. state of West Virginia, and forms part of the Wheeling metropolitan area. As of the 2020 census, the population was 42,425. Its county seat is Wheeling. The county was formed in 1776 from the District of West Augusta, Virginia. It was named for the Ohio River, which forms its western boundary with the state of Ohio. West Liberty was designated as the county seat in 1777, serving to 1797.