Keowee Key is a lakeside community and census-designated place in Oconee County, South Carolina, United States. It is considered part of the Salem community. It was first listed as a CDP prior to the 2020 census with a population of 2,716. The CDP is on the eastern edge of Oconee County, on a peninsula extending into Lake Keowee, a reservoir on the Keowee River and Little River.