Dothan is a city in and the county seat of Houston County in the U.S. state of Alabama. A slight portion of the city extends into Dale and Henry counties. It is Alabama's eighth-largest city, with a population of 71,072 at the 2020 census, and the 5th largest in Alabama by total Area. It is near the state's southeastern corner, about 20 miles west of Georgia and 16 miles north of Florida.