Columbus is a city in and the county seat of Lowndes County, on the eastern border of Mississippi, United States, located primarily east, but also north and northeast of the Tombigbee River, which is also part of the Tennessee-Tombigbee Waterway. It is approximately 146 miles northeast of Jackson, 92 miles north of Meridian, 63 miles south of Tupelo, 60 miles northwest of Tuscaloosa, Alabama, and 120 miles west of Birmingham, Alabama.