Childersburg is a city in Talladega County in the U.S. state of Alabama. It was incorporated in 1889. At the 2020 census, the population was 4,754. It has a history dating back before 1540, when it was noted as a village of the Coosa Nation visited by the Spanish explorer Hernando de Soto. It is said a member of De Soto’s crew fell ill and was left to settle in the area of present day Childersburg where the Coosa people cared for the ill explorer.