Little Hocking is a census-designated place in southern Belpre Township, Washington County, Ohio, United States. It has a post office with the ZIP code 45742. The population of the CPD was 244 at the 2020 census. Little Hocking lies along the Ohio River south of Marietta. It sits at the intersection of U.S. Route 50 with State Route 124 and County Road 26, where the Little Hocking River meets the Ohio River.