Sena Madureira is a municipality located in the center of the Brazilian state of Acre. Its population is 46,511 and its area is 25,278 square kilometres, making it the largest municipality in the state. It has a climate which combines temperatures of 78 °F with humidities in the upper 90s percent, all year round. It is 143 km from Rio Branco. The oldest church in Acre state is located in Sena Madureira, the Nossa Senhora da Imaculada Conceição Church.