Clark's Harbour is a town on Cape Sable Island in southwestern Nova Scotia, Canada, located in Shelburne County. The main industry is lobster fishing. Owing to this as well as the town's history as a fishing community, the town is noted as the birthplace of the Cape Islander fishing boat. The community is the southernmost town in the province of Nova Scotia, and thus one of the southernmost towns in Canada, being located roughly on a parallel with Bilbao, Basque Country and just north of Rome.