Clare is a city in the U.S. state of Michigan. Located near the center of Michigan's Lower Peninsula, the city is located mostly in Clare County, while a small portion extends south into Isabella County. The city had a population of 3,254 at the 2020 census. Clare was settled as early as 1870 and contains two listings on the National Register of Historic Places: the Clare Downtown Historic District and the Clare Congregational Church. The city is located along the junction of U.S. Route 10 and U.S. Route 127, and each highway has a business route through the downtown area.