Desha is an unincorporated community and census-designated place in Independence County, Arkansas, United States. It was first listed as a CDP in the 2020 census with a population of 715.Desha is located along Arkansas Highway 25, 3 miles southwest of Batesville. Desha has a post office with ZIP code 72527.Batesville School District operates area public schools. The Desha School District merged into the Batesville district on July 1, 1985.