Bithlo is a census-designated place and an unincorporated community in Orange County, Florida, United States. The population was 8,268 at the 2010 census, up from 4,626 at the 2000 census. It is part of the Orlando–Kissimmee Metropolitan Statistical Area. The Bithlo Post Office opened in 1922. For 20 years in the early 20th century, Bithlo was an incorporated town, but in 1929 ceased to function as a town due to economic hardship.