St. Clair County is a county located in the U.S. state of Michigan and bordering the west bank of the St. Clair River. As of the 2020 census, the population was 160,383. It is the 13th-most populous county in the state. The county seat is Port Huron, located at the north end of the St. Clair River at Lake Huron. The county was created September 10, 1820, and its government was organized in 1821. It is located northeast of Detroit.