Keefton is an unincorporated community and census-designated place in Muskogee County, Oklahoma, United States. The community is on U.S. Highway 64, 11 miles south of downtown Muskogee. On May 23, 1973 an F4 tornado hit Keefeton directly, obliterating 75% of the town. The tornado traveled in a SW to NE direction, with 5 deaths—4 of which were in a pickup truck that was rolled for approximately 1/2 mile. A tornado measuring EF1 on the Enhanced Fujita Scale struck near Keefeton on May 15, 2020.