Itasca County is a county located in the Iron Range region of the U.S. state of Minnesota. As of the 2020 census, the population was 45,014. Its county seat is Grand Rapids. The county is named after Lake Itasca, which is in turn a shortened version of the Latin words veritas caput, meaning 'truth' and 'head', a reference to the source of the Mississippi River. Portions of the Bois Forte and Leech Lake Indian reservations are in the county.