The Missouri River is a river in the Central and Mountain West regions of the United States. The nation's longest, it rises in the eastern Centennial Mountains of the Bitterroot Range of the Rocky Mountains of southwestern Montana, then flows east and south for 2,341 miles before entering the Mississippi River north of St. Louis, Missouri. The river drains semi-arid watershed of more than 500,000 square miles, which includes parts of ten U.S. states and two Canadian provinces.