Middlesex Centre is a township in Middlesex County, in southwestern Ontario, Canada, north and west of London. The Corporation of the Township of Middlesex Centre formed on January 1, 1998, with the amalgamation of the former Townships of Delaware, Lobo, and London. It is part of the London census metropolitan area. Middlesex Centre is halfway between two of the five Great Lakes. It is north of Lake Erie, and southeast of Lake Huron.