Kernersville is a town in Forsyth County, in the U.S. state of North Carolina. A small portion of the town is also in Guilford County. The population was 23,123 at the 2010 census, up from 17,126 at the 2000 census. Kernersville is located at the center of the Piedmont Triad metropolitan area, between Greensboro to the east, High Point to the south, and Winston-Salem to the west.