Kernersville is a town in Forsyth County, North Carolina, and the largest suburb of Winston-Salem. A small portion of the town is also in Guilford County. The population was 26,481 at the 2020 census, up from 23,123 in 2010. Kernersville is located at the center of the Piedmont Triad metropolitan area, between Greensboro to the east, High Point to the south, and Winston-Salem to the west.