Sloughhouse is an unincorporated community in Sacramento County, California, United States. Sloughhouse is located on California State Route 16, 17 miles east-southeast of downtown Sacramento. Sloughhouse has a post office with ZIP code 95683, which was established in 1916. Jared Sheldon, who built a roadhouse, hotel and Stagecoach station, in the community in 1850, named the community after another building he had built nearby. The roadhouse was destroyed by a fire in 1890, but was rebuilt.