Paxville is a town in Clarendon County, South Carolina, United States. The population was 185 at the 2010 census, down from 248 in 2000. The town was named after Joseph Pack. Joseph Pack and his wife, Louisa Alexandria Pack, arrived in America from England in the year 1770. He became one of the most extensive land holders in the Carolina Low Country, having acquired more than 10,000 acres of land. He helped found the town of Packsville.