Sant'Onofrio is a comune in the Province of Vibo Valentia in the Italian region Calabria, located about 45 kilometres southwest of Catanzaro and about 4 kilometres northeast of Vibo Valentia. As of 31 December 2004, it had a population of 3,202 and an area of 18.4 square kilometres. It is named after Saint Onuphrius. Sant'Onofrio borders the following municipalities: Filogaso, Maierato, Pizzo, Stefanaconi, Vazzano, Vibo Valentia.