The Dr. William W. Mayo House, located at 118 North Main Street in Le Sueur, Minnesota, United States, is listed on the National Register of Historic Places. It was built in 1859 by James Mayo and his brother, William Worrall Mayo who emigrated from Salford, United Kingdom, to the United States in 1846 and became a doctor. William's older son, William James Mayo was born in the home in 1861. William W.