Cowlitz County is a county located in the U.S. state of Washington. As of the 2020 census, its population was 110,730. The county seat is Kelso, and its largest city is Longview. The county was formed in April 1854. Its name derives from the anglicized version of the Cowlitz Indian term Cow-e-liske, meaning either 'river of shifting sands' or 'capturing the medicine spirit.'