Bluffton is a town in southern Beaufort County, South Carolina, United States. The population as of the 2020 census was 27,716, an increase of over 120% since 2010, making it one of the fastest growing municipalities in South Carolina. Bluffton is the fifth-most populous municipality in South Carolina by land area. It is primarily located around U.S. Route 278, between Hilton Head Island and Interstate 95.