Harrodsburg is a home rule-class city in Mercer County, Kentucky, United States. It is the seat of its county. The population was 9,064 at the 2020 census. Although Harrodsburg was formally established by the Virginia House of Burgesses after Boonesborough and was not incorporated by the Kentucky legislature until 1836, it was honored by President Franklin D. Roosevelt as the oldest permanent American settlement west of the Appalachians.