South Bend is a city in and the county seat of St. Joseph County, Indiana, United States, on the St. Joseph River near its southernmost bend, from which it derives its name. At the 2020 census, the city had a total of 103,453 residents and is the fourth-largest city in Indiana. Located just south of the border with Michigan, South Bend anchors the Michiana region and is 72 miles east of downtown Chicago.