Jacksonville is a city located in Cherokee County, Texas, United States. The population was 13,997 at the 2020 U.S. census. It is the principal city of the Jacksonville micropolitan statistical area, which includes all of Cherokee County. Jacksonville is located in East Texas, north of the county seat, Rusk, and south of Tyler, in Smith County. Area production and shipping of tomatoes gained the town the title "Tomato Capital of the World".