St. Joseph is a neighborhood two miles south of downtown Louisville, Kentucky, United States, and immediately east of the University of Louisville. It borders the Meriwether neighborhood to the north and Schnitzelburg to the east. The area was named after the St. Joseph's Infirmary hospital, which was established by the Sisters of Charity of Nazareth. The building, once located at the corner of Preston Street and Eastern Parkway, was razed in 1980.