Thompsonville is a village in Benzie County in the U.S. state of Michigan. The village had a population of 451 at the 2020 census, up from 441 at the 2010 census. The village lies immediately north of the Manistee County line, and is divided between Colfax and Weldon townships. Crystal Mountain, one of Michigan's largest ski resorts, is located just west of Thompsonville.