Drew County is a county located in the southeast region of the U.S. state of Arkansas. As of the 2020 census, the population was 17,350. The county seat and largest city is Monticello. Drew County was formed on November 26, 1846, and named for Thomas Drew, the third governor of Arkansas. Located on the edge of the Arkansas Delta and the Arkansas Timberlands, its fertile lowland soils produced prosperity for early settlers in the antebellum era.