Pontotoc is a city in and the county seat of Pontotoc County, Mississippi, located to the west of the larger city of Tupelo. The population was 5,640 at the 2020 census. Pontotoc is a Chickasaw word that means, “Land of the Hanging Grapes.” A section of the city largely along Main Street and Liberty Street has been designated the Pontotoc Historic District and is listed on the National Register of Historic Places. The Treaty of Pontotoc Site is also listed on the National Register.